James C A, Watson A R, Twining P, Rance C H
Children and Young Peoples Renal Unit, City Hospital NHS Trust, Nottingham, UK.
Eur J Pediatr. 1998 Jun;157(6):508-11. doi: 10.1007/s004310050865.
To define the incidence of urinary tract abnormalities detected by antenatal ultrasound and assess changes in postnatal management we conducted a retrospective survey using data bases of the nephro-urology unit, obstetric ultrasound and perinatal pathology departments. The birth population (105,542) of the two Nottingham teaching hospitals between January 1984 and December 1993 was divided into two 5-year cohorts, 1984-1988 and 1989-1993. Detailed fetal scanning at 18-20 weeks gestation was introduced in 1989. During this 10-year period, 201 abnormalities of the urinary tract were noted with a 2:1 male to female ratio. The incidence of abnormalities in the first 5 years was 1 in 964 compared to 1 in 364 in the last 5 years. There was a significant increase in the number detected before 20 weeks gestation (12% in 1984-1988 compared to 62% in 1989-1993). Despite the increased incidence of abnormalities detected, the termination rate remained static between the two 5-year cohorts. Only 3 fetuses had intra-uterine intervention and 173 were live-born. Eight infants subsequently died in association with other major congenital abnormalities. The incidence of transient abnormalities (antenatal dilatation with no abnormality noted on postnatal ultrasound) increased from 6% in 1984-1988 to 18% in the 1989-1993 cohort. A more conservative approach to postnatal management is reflected by 71% of infants having operations between 1984 and 1988 compared to 35% in 1989-1993.
The advent of detailed fetal scanning at 18-20 weeks gestation has significantly increased the detection rate of urinary tract abnormalities with no significant increase in pregnancy termination rates. The need for antenatal intervention is a rare event and most problems can be managed conservatively both pre- and postnatally.
为确定产前超声检测出的泌尿系统异常的发生率,并评估产后管理的变化,我们利用肾泌尿外科、产科超声及围产期病理科的数据库进行了一项回顾性调查。1984年1月至1993年12月期间,两所诺丁汉教学医院的出生人口(105,542人)被分为两个5年队列,即1984 - 1988年队列和1989 - 1993年队列。1989年开始在妊娠18 - 20周时进行详细的胎儿扫描。在这10年期间,共发现201例泌尿系统异常,男女比例为2:1。前5年异常发生率为1/964,后5年为1/364。妊娠20周前检测出的异常数量显著增加(1984 - 1988年为12%,1989 - 1993年为62%)。尽管检测出的异常发生率有所增加,但两个5年队列间的终止妊娠率保持稳定。只有3例胎儿接受了宫内干预,173例为活产。8名婴儿随后因其他主要先天性异常死亡。短暂性异常(产前扩张,产后超声未发现异常)的发生率从1984 - 1988年的6%增至1989 - 1993年队列的18%。1984年至1988年期间71%的婴儿接受了手术,而在1989 - 1993年这一比例为35%,这反映出产后管理采取了更为保守的方法。
妊娠18 - 20周详细胎儿扫描的出现显著提高了泌尿系统异常的检测率,而妊娠终止率没有显著增加。产前干预的需求很少见,大多数问题在产前和产后都可以保守处理。