Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5, and beta-4 subunits of neuronal nicotinic acetylcholine receptors. Preferential transcription of the alpha-3 and beta-4 genes by immature CD4+8+ thymocytes and evidence for response to nicotine in thymocytes. - Suppr | 超能文献

Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5, and beta-4 subunits of neuronal nicotinic acetylcholine receptors. Preferential transcription of the alpha-3 and beta-4 genes by immature CD4+8+ thymocytes and evidence for response to nicotine in thymocytes.

作者信息

Mihovilovic M, Denning S, Mai Y, Fisher C M, Whichard L P, Patel D D, Roses A D

机构信息

Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

出版信息

Ann N Y Acad Sci. 1998 May 13;841:388-92. doi: 10.1111/j.1749-6632.1998.tb10951.x.

DOI:10.1111/j.1749-6632.1998.tb10951.x

Abstract

摘要

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Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5, and beta-4 subunits of neuronal nicotinic acetylcholine receptors. Preferential transcription of the alpha-3 and beta-4 genes by immature CD4+8+ thymocytes and evidence for response to nicotine in thymocytes.

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Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5 and beta-4 subunits of neuronal nicotinic acetylcholine receptors: preferential transcription of the alpha-3 and beta-4 genes by immature CD4 + 8 + thymocytes.

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Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.胸腺上皮细胞在体外为CD4+CD8+胸腺细胞的阳性选择提供独特信号。

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