Watt D, Kiara H, Sparagano O A
Centre for Tropical Veterinary Medicine, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Scotland, UK.
Ann N Y Acad Sci. 1998 Jun 29;849:69-77. doi: 10.1111/j.1749-6632.1998.tb11035.x.
Theileria parva is a hemoprotozoan parasite responsible for causing East Coast fever in east and central Africa. The vaccine currently available is an "infection and treatment" procedure which involves the injection of live sporozoites followed by drug therapy to prevent clinical illness. Before introducing potentially new strains of parasite into an area, however, it is crucial to check the disease situation in the field first. We looked at three different areas in Kenya: Limuru in which many cattle have already been vaccinated and Kitale and Kakamega which so far have not been vaccinated. Genus and species specific primers were used to test for the presence of Theileria species in blood and tick samples collected from the three areas. Limuru showed a cattle and tick infection prevalence of 27% and 2.3% respectively with T. parva. Kitale showed a cattle and tick infection prevalence of 100% and 14.2% respectively while Kakamega showed 100% and 0% respectively. Reasons for variations between areas involving vaccination status and epidemiological data are discussed.
小泰勒虫是一种血液原虫寄生虫，可导致东非和中非的东海岸热。目前可用的疫苗是一种“感染与治疗”程序，包括注射活的子孢子，随后进行药物治疗以预防临床疾病。然而，在将潜在的新寄生虫菌株引入一个地区之前，首先检查该地区的疾病情况至关重要。我们考察了肯尼亚的三个不同地区：许多牛已经接种过疫苗的Limuru，以及迄今尚未接种过疫苗的基塔莱和卡卡梅加。使用属和种特异性引物检测从这三个地区采集的血液和蜱样本中是否存在泰勒虫属物种。Limuru地区感染小泰勒虫的牛和蜱的患病率分别为27%和2.3%。基塔莱地区感染小泰勒虫的牛和蜱的患病率分别为100%和14.2%，而卡卡梅加地区分别为100%和0%。文中讨论了不同地区之间在疫苗接种状况和流行病学数据方面存在差异的原因。
