Valentin L, Marsál K
Department of Obstetrics and Gynecology, University Hospital MAS, University of Lund, Malmö, Sweden.
Ann N Y Acad Sci. 1998 Jun 18;847:59-73. doi: 10.1111/j.1749-6632.1998.tb08927.x.
A review of the literature is presented. Congenital renal and urinary tract anomalies are described, and the possible consequences of detecting them in utero are discussed. Prenatal detection of lethal anomalies affords the parents the option of terminating the pregnancy. If termination of pregnancy is not an acceptable option for the parents, the antenatal knowledge of lethal fetal anomaly helps the clinician to avoid unnecessary obstetric intervention, e.g., cesarean delivery for fetal distress. In certain cases of nonlethal renal and urinary tract anomalies, antenatal detection may influence both obstetric and postnatal management. It seems reasonable to anticipate that this might improve the prognosis of some children in terms of better preservation of kidney function. However, no scientific evidence is available to support such a statement. There are no randomized trials evaluating the outcome of congenital renal and urinary tract anomalies using different prenatal and postnatal diagnostic and therapeutic approaches. It is hoped that further research will lead to more rational antenatal and postnatal management protocols.
本文献综述介绍了先天性肾和尿路异常,并讨论了在子宫内检测到这些异常可能产生的后果。产前检测到致命性异常为父母提供了终止妊娠的选择。如果终止妊娠对父母来说不是一个可接受的选择,那么产前知晓致命性胎儿异常有助于临床医生避免不必要的产科干预,例如因胎儿窘迫而行剖宫产。在某些非致命性肾和尿路异常的情况下,产前检测可能会影响产科和产后管理。预计这可能会在更好地保护肾功能方面改善一些儿童的预后,这似乎是合理的。然而,尚无科学证据支持这一说法。目前没有随机试验评估使用不同的产前和产后诊断及治疗方法对先天性肾和尿路异常的结果。希望进一步的研究将导致更合理的产前和产后管理方案。