Grandjean H, Larroque D, Levi S
INSERM, Hôpital La Grave, Toulouse, France.
Ann N Y Acad Sci. 1998 Jun 18;847:118-24. doi: 10.1111/j.1749-6632.1998.tb08932.x.
In this prospective study, we recorded details on 3,685 fetuses with congenital structural abnormalities from an unselected population of women who underwent routine ultrasound examinations during their pregnancies. Overall, 2,262 fetuses were diagnosed as being abnormal before birth (sensitivity = 61.4%). The total number of abnormalities was 4,615, of which 1,733 (37.5%) were major abnormalities. The overall number of detected abnormalities was 2,593 (sensitivity = 56.2%). If only major abnormalities were considered, the sensitivity rose to 73.7%, compared to only 45.7% for the minor abnormalities. Within each severity group, the accuracy of detection varied across systems. For the major abnormalities, it was higher for the central nervous system (88.3%) and urinary tract (84.8%), but lower for heart and great vessels (38.8%). Detection of minor abnormalities was also effective for the urinary tract (89.1%), but not for the heart and great vessels (20.8%) and the musculoskeletal system (18%).
在这项前瞻性研究中，我们记录了来自未经过筛选的孕妇群体中3685例患有先天性结构异常胎儿的详细信息，这些孕妇在孕期接受了常规超声检查。总体而言，2262例胎儿在出生前被诊断为异常（敏感性=61.4%）。异常总数为4615例，其中1733例（37.5%）为主要异常。检测到的异常总数为2593例（敏感性=56.2%）。如果仅考虑主要异常，敏感性升至73.7%，而次要异常仅为45.7%。在每个严重程度组中，各系统的检测准确性有所不同。对于主要异常，中枢神经系统（88.3%）和泌尿系统（84.8%）的检测准确性较高，但心脏和大血管的检测准确性较低（38.8%）。次要异常的检测在泌尿系统中也很有效（89.1%），但在心脏和大血管（20.8%）以及肌肉骨骼系统（18%）中效果不佳。
