• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

氯氮平治疗早期出现的肝炎、高血糖、胸腔积液、嗜酸性粒细胞增多、血尿和蛋白尿。

Hepatitis, hyperglycemia, pleural effusion, eosinophilia, hematuria and proteinuria occurring early in clozapine treatment.

作者信息

Thompson J, Chengappa K N, Good C B, Baker R W, Kiewe R P, Bezner J, Schooler N R

机构信息

University of Pittsburgh School of Medicine, PA, USA.

出版信息

Int Clin Psychopharmacol. 1998 Mar;13(2):95-8. doi: 10.1097/00004850-199803000-00007.

DOI:10.1097/00004850-199803000-00007
PMID:9669191
Abstract

This report describes a 48-year-old caucasian male with schizophrenia who developed hepatitis, hyperglycemia, pleural effusion, eosinophilia, hematuria and proteinuria early in clozapine treatment which resolved on drug discontinuation. The literature on similar cases is reviewed.

摘要

本报告描述了一名48岁患有精神分裂症的白种男性，在氯氮平治疗早期出现肝炎、高血糖、胸腔积液、嗜酸性粒细胞增多、血尿和蛋白尿，停药后症状缓解。并对类似病例的文献进行了综述。

相似文献

1
Hepatitis, hyperglycemia, pleural effusion, eosinophilia, hematuria and proteinuria occurring early in clozapine treatment.氯氮平治疗早期出现的肝炎、高血糖、胸腔积液、嗜酸性粒细胞增多、血尿和蛋白尿。
Int Clin Psychopharmacol. 1998 Mar;13(2):95-8. doi: 10.1097/00004850-199803000-00007.
2
Pericardial and bilateral pleural effusion associated with clozapine treatment.与氯氮平治疗相关的心包积液和双侧胸腔积液
Eur Psychiatry. 2004 Feb;19(1):65. doi: 10.1016/j.eurpsy.2003.10.003.
3
Cellulitis, eosinophilia, and unilateral pleural effusion associated with clozapine treatment.
J Clin Psychopharmacol. 1997 Jun;17(3):232-3. doi: 10.1097/00004714-199706000-00022.
4
Allergic to Clozapine: A Case of Clozapine-Associated Eosinophilia With Pleural Effusions Followed by Pancreatitis on Clozapine Rechallenge.对氯氮平过敏：一例氯氮平相关嗜酸性粒细胞增多伴胸腔积液，再次使用氯氮平后并发胰腺炎的病例。
J Clin Psychopharmacol. 2020 Mar/Apr;40(2):199-200. doi: 10.1097/JCP.0000000000001187.
5
Papular rash and bilateral pleural effusion associated with clozapine.
Ann Pharmacother. 1999 Sep;33(9):1008-9. doi: 10.1345/aph.19038.
6
Eosinophilic pleural effusion associated with the addition of sodium valproate.与丙戊酸钠添加相关的嗜酸性胸腔积液。
J Clin Psychopharmacol. 2009 Jun;29(3):310-1. doi: 10.1097/JCP.0b013e3181a2e1cf.
7
Successful rechallenge with clozapine after eosinophilia.嗜酸性粒细胞增多后成功再次使用氯氮平治疗。
Am J Psychiatry. 2011 Nov;168(11):1147-51. doi: 10.1176/appi.ajp.2010.10040519.
8
Clozapine-induced toxic hepatitis with skin rash.
J Psychopharmacol. 2005 Jan;19(1):107. doi: 10.1177/0269881105047287.
9
Clozapine-induced eosinophilia: subsequent neutropenia and corresponding allergic mechanisms.氯氮平诱导的嗜酸性粒细胞增多症：随后的中性粒细胞减少症及相应的过敏机制。
J Clin Psychiatry. 1998 Apr;59(4):195-7.
10
Clozapine-induced peripheral and pleural fluid eosinophilia.氯氮平引起的外周和胸腔液嗜酸性粒细胞增多。
Ann Pharmacother. 2012 Feb;46(2):e4. doi: 10.1345/aph.1Q642. Epub 2012 Jan 24.

引用本文的文献

1
Clozapine-Related Diarrhea and Colitis: Report of 4 Cases.氯氮平相关性腹泻和结肠炎：4 例报告。
J Clin Psychopharmacol. 2020 May/Jun;40(3):293-296. doi: 10.1097/JCP.0000000000001204.
2
A Rare Presentation of Clozapine-Induced DRESS Syndrome.氯氮平诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征的罕见表现。
Case Rep Med. 2018 Jun 11;2018:1346351. doi: 10.1155/2018/1346351. eCollection 2018.
3
Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report.氯氮平治疗开始后多器官嗜酸性粒细胞浸润：一例报告
BMC Res Notes. 2017 Jul 25;10(1):316. doi: 10.1186/s13104-017-2662-1.
4
Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity.精神药物与肝脏疾病：药代动力学及肝脏毒性的批判性综述
World J Gastrointest Pharmacol Ther. 2017 Feb 6;8(1):26-38. doi: 10.4292/wjgpt.v8.i1.26.
5
Hepatic Safety of Atypical Antipsychotics: Current Evidence and Future Directions.非典型抗精神病药物的肝脏安全性：当前证据与未来方向。
Drug Saf. 2016 Oct;39(10):925-43. doi: 10.1007/s40264-016-0436-7.
6
Eosinophilia induced by clozapine: a report of two cases and review of the literature.氯氮平诱发的嗜酸性粒细胞增多症：两例报告及文献复习
J Family Med Prim Care. 2015 Jan-Mar;4(1):127-9. doi: 10.4103/2249-4863.152269.
7
Clozapine-induced liver injury and pleural effusion.氯氮平引起的肝损伤和胸腔积液。
Ment Illn. 2014 Sep 8;6(2):5403. doi: 10.4081/mi.2014.5403. eCollection 2014 Sep 2.
8
Hepatotoxicity induced by clozapine: a case report and review of literature.氯氮平引起的肝毒性：病例报告及文献复习。
Neuropsychiatr Dis Treat. 2014 Aug 26;10:1585-7. doi: 10.2147/NDT.S67654. eCollection 2014.
9
Eosinophilia, pleural effusion, hepatitis, and jaundice occurring early in clozapine treatment.氯氮平治疗早期出现嗜酸性粒细胞增多、胸腔积液、肝炎和黄疸。
Clin Psychopharmacol Neurosci. 2013 Aug;11(2):103-5. doi: 10.9758/cpn.2013.11.2.103. Epub 2013 Aug 26.
10
Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review.第二代（非典型）抗精神病药物与代谢效应：一项全面的文献综述
CNS Drugs. 2005;19 Suppl 1:1-93. doi: 10.2165/00023210-200519001-00001.