西沙必利对II型糖尿病患者胃节律紊乱及难消化固体排空的影响。

Effect of cisapride on gastric dysrhythmia and emptying of indigestible solids in type-II diabetic patients.

作者信息

Chang C S, Lien H C, Yeh H Z, Poon S K, Tung C F, Chen G H

机构信息

Dept. of Internal Medicine, Taichung Veterans General Hospital, Taiwan.

出版信息

Scand J Gastroenterol. 1998 Jun;33(6):600-4. doi: 10.1080/00365529850171864.

DOI:10.1080/00365529850171864

PMID:9669631

Abstract

BACKGROUND

Abnormal gastric slow-wave frequencies have been observed in diabetic gastroparesis. To evaluate the effect of cisapride on gastric dysrhythmia and emptying of indigestible solids, 20 type-II diabetic patients with symptoms suggestive of gastroparesis were enrolled in this study.

METHODS

Cutaneous electrogastrography, gastric emptying of radiopaque markers, and evaluation of upper gastrointestinal symptoms were performed before and after administration of an 8-week course of cisapride.

RESULTS

The fasting-state percentages of dominant frequency in normal and tachygastric ranges improved significantly after an 8-week course of cisapride treatment (P < 0.01 and P < 0.05, respectively). The post-meal percentages of dominant frequency in the tachygastric range also improved significantly after cisapride treatment (P < 0.05). The upper gastrointestinal symptoms score decreased significantly, and gastric emptying of radiopaque markers also increased significantly after 8 weeks of cisapride treatment (P < 0.01).

CONCLUSIONS

In conclusion, this study showed that cisapride can improve gastric dysrhythmia during both fasting and post-meal phases in patients with diabetic gastroparesis. In addition, upper GI symptoms and gastric emptying of indigestible solids may also show significant improvement after 8 weeks of cisapride treatment.

摘要

背景

在糖尿病胃轻瘫患者中观察到胃慢波频率异常。为评估西沙必利对胃节律紊乱和难消化固体排空的影响，本研究纳入了20例有胃轻瘫症状提示的II型糖尿病患者。

方法

在给予为期8周的西沙必利疗程前后，进行皮肤胃电图检查、不透X线标志物的胃排空检查以及上消化道症状评估。

结果

经过8周的西沙必利治疗后，正常和快速胃电频率范围内的空腹状态主导频率百分比显著改善（分别为P < 0.01和P < 0.05）。西沙必利治疗后，快速胃电频率范围内的餐后主导频率百分比也显著改善（P < 0.05）。经过8周的西沙必利治疗后，上消化道症状评分显著降低，不透X线标志物的胃排空也显著增加（P < 0.01）。