西沙必利对无胃肠道症状的糖尿病患者胃排空的影响。

Effect of cisapride on gastric emptying in diabetic patients without gastrointestinal symptoms.

作者信息

Kasai S, Tanaka K, Machimura H, Takeda H, Kaneshige H, Sakai H, Harasawa S

机构信息

Department of Internal Medicine, School of Medicine, Tokai University, Kanagawa.

出版信息

Tokai J Exp Clin Med. 1991 Jul;16(2):97-102.

PMID:1780919

Abstract

The long-team effects of cisapride on gastric emptying and hormonal interaction in diabetic patients without gastrointestinal symptoms was evaluated. Gastric emptying was determined by the N-acetyl-p-amino-phenol (APAP) method before and after cisapride treatment. Gastric emptying improved significantly, from 5.95 to 8.04 micrograms/ml, after 6 weeks of treatment. Plasma concentrations of immunoreactive insulin (IRI), after 30 and 45 minutes in the gastric emptying test, increased significantly after treatment. It appeared that improvement of gastric emptying after loading with cisapride might be related to improved insulin secretion in diabetic patients without subjective symptoms of gastroparesis.

摘要

评估了西沙必利对无胃肠道症状的糖尿病患者胃排空及激素相互作用的长期影响。采用对乙酰氨基酚（APAP）法在西沙必利治疗前后测定胃排空情况。治疗6周后，胃排空显著改善，从5.95微克/毫升提高到8.04微克/毫升。在胃排空试验中，治疗后30分钟和45分钟时血浆免疫反应性胰岛素（IRI）浓度显著升高。似乎西沙必利负荷后胃排空的改善可能与无胃轻瘫主观症状的糖尿病患者胰岛素分泌改善有关。