Brousset P, Chaouche N, Al Saati T, Zenou R C, Delsol G
Laboratoire du Groupe d'Etude des Lymphomes Malins (CNRS, UPCM), Centre Hospitalier Universitaire de Purpan, Toulouse, France.
Leuk Lymphoma. 1998 Jun;30(1-2):189-92. doi: 10.3109/10428199809050942.
Telomerase activity has been demonstrated in various types of cancers including lymphoid neoplasms. The tumour specificity of telomerase activity has been a subject of debate since the description of detectable enzymatic activity in non neoplastic tissues. We and others have demonstrated that such activity was present in non Hodgkin's lymphomas as well as in reactive hyperplastic lymph nodes and tonsils. However, we at the same time were surprised by the absence of telomerase activity in most cases of Hodgkin's disease. We have extended our previous study by adding additional cases and confirm that in the majority of cases, Hodgkin and Reed-Sternberg cells lack telomerase activity (only 2 cases positive out of 20). These results may indicate that the tumour cells of Hodgkin's disease evolve different pathways for maintaining the length of their telomeres during the process of becoming immortal.
端粒酶活性已在包括淋巴瘤在内的各种癌症类型中得到证实。自从在非肿瘤组织中发现可检测的酶活性以来，端粒酶活性的肿瘤特异性一直是一个争论的话题。我们和其他人已经证明，这种活性存在于非霍奇金淋巴瘤以及反应性增生性淋巴结和扁桃体中。然而，与此同时，我们惊讶地发现大多数霍奇金病病例中不存在端粒酶活性。我们通过增加更多病例扩展了我们之前的研究，并证实大多数情况下，霍奇金和里德-斯腾伯格细胞缺乏端粒酶活性（20例中只有2例呈阳性）。这些结果可能表明，霍奇金病的肿瘤细胞在永生化过程中进化出了不同的维持端粒长度的途径。
