Bieroń K, Swies J, Kostka-Trabka E, Gryglewski R J
Jagiellonian University Medical School, Cracow, Poland.
J Physiol Pharmacol. 1998 Jun;49(2):241-9.
Here we report on thrombolytic and hypotensive actions of Xanthinol nicotinate (Sadamin) in rats and on its anti-platelet and fibrinolytic effects in patients with peripheral arterial obliterative disease (PAOD). Special consideration was given to a proposal of new mechanisms of anti-platelet and thrombolytic actions of Sadamin. We conclude that the mechanism of anti-platelet and thrombolytic activity of Sadamin partly consists of a simultaneous release of endogenous prostacyclin and nitric oxide by the nicotinate component of Sadamin, whereas the theophylline component is responsible for enhancement of physiological actions of these endothelial mediators at the level of cyclic nucleotides which are their second messengers.
在此，我们报告了烟酸占替诺（脉栓通）在大鼠中的溶栓和降压作用，以及其对周围动脉闭塞性疾病（PAOD）患者的抗血小板和纤溶作用。特别考虑了脉栓通抗血小板和溶栓作用新机制的提议。我们得出结论，脉栓通抗血小板和溶栓活性的机制部分包括脉栓通的烟酸成分同时释放内源性前列环素和一氧化氮，而茶碱成分则负责在作为这些内皮介质第二信使的环核苷酸水平增强这些内皮介质的生理作用。
