Engenhart-Cabillic R, Debus J, Prott F J, Pötter R, Höver K H, Breteau N, Krüll A
Department of Radiotherapy, Medical Radiology Center, Marburg, Germany.
Recent Results Cancer Res. 1998;150:113-24. doi: 10.1007/978-3-642-78774-4_6.
Inoperable locally advanced or inoperable recurrent rectal cancer is a difficult problem. Tenesmus, discharge, bleeding and pelvic pain are frequently present and often are associated with infiltration of the sacral plexus. The value of radiotherapy in managing such patients is being appreciated, although up to 40% of the treated patients have no symptomatic response. Improvement in tumor response and control has been scored through efforts to overcome the radio resistance of the hypoxic tumor cells by neutron irradiation. This article is an account of the activity of neutron radiotherapy in such patients. Over 350 patients were entered in studies comparing neutrons used alone and neutrons used in a mixed-beam treatment schedule. At present no therapeutic gain for long-lasting survival has been achieved; however, local control and pain improvement seems to be better with neutrons than with photons.
无法手术的局部晚期或无法手术的复发性直肠癌是一个难题。里急后重、排液、出血和盆腔疼痛很常见，且常与骶丛神经浸润有关。尽管高达40%的接受治疗的患者没有症状缓解，但放疗在治疗这类患者中的价值正得到认可。通过中子照射克服缺氧肿瘤细胞的放射抗性的努力，已在肿瘤反应和控制方面取得了进展。本文介绍了中子放疗在这类患者中的应用情况。超过350名患者参与了比较单独使用中子和在混合束治疗方案中使用中子的研究。目前尚未实现长期生存的治疗获益；然而，与光子相比，中子在局部控制和疼痛改善方面似乎更好。
