Rajaram S, Sedensky M M, Morgan P G
Departments of Anesthesiology and Genetics, University Hospitals, Case Western Reserve University, Cleveland, OH 44106, USA.
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8761-6. doi: 10.1073/pnas.95.15.8761.
To identify sites of action of volatile anesthetics, we are studying genes in a functional pathway that controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans. The unc-1 gene occupies a central position in this pathway. Different alleles of unc-1 have unique effects on sensitivity to the different volatile anesthetics. UNC-1 shows extensive homology to human stomatin, an integral membrane protein thought to regulate an associated ion channel. We postulate that UNC-1 has a direct effect on anesthetic sensitivity in C. elegans and may represent a molecular target for volatile anesthetics.
为了确定挥发性麻醉剂的作用位点,我们正在研究线虫秀丽隐杆线虫中控制对挥发性麻醉剂敏感性的功能途径中的基因。unc-1基因在该途径中占据中心位置。unc-1的不同等位基因对不同挥发性麻醉剂的敏感性有独特影响。UNC-1与人类 stomatin 具有广泛的同源性,stomatin 是一种被认为可调节相关离子通道的整合膜蛋白。我们推测UNC-1对线虫的麻醉敏感性有直接影响,并且可能代表挥发性麻醉剂的分子靶点。