Dey Abira, Ganguly Debabani
Centre for Health Science and Technology (CHeST), JIS Institute of Advanced Studies and Research (JISIASR) Kolkata, JIS University, JIS School of Medical Science and Research Campus, Santragachi, Howrah, West Bengal, 711112, India.
J Membr Biol. 2025 Jul 10. doi: 10.1007/s00232-025-00355-2.
Stomatin, encoded by STOM gene, is an integral membrane protein found in a wide variety of species. Although years have passed since the identification of stomatin, little has been known about the functional insights of stomatin among which stomatin undergoing homo-oligomerization, post and reverse-post modifications are the notable ones. Stomatin downregulation or overexpression is directly connected to its ability to control neutrophil degranulation, modulate activities of transporter proteins, and mediate cancer metastasis. Stomatin shares about 40-80% sequence similarity at its signature SPFH (stomatin, prohibitin, flotillin and Hlfk) domain region with the stomatin-like proteins (SLPs). Although stomatin and SLPs are reported to have various therapeutic activities, still gaps are there regarding their plausible mechanistic insights. Therefore, in future, studies should be aimed toward investigating the possible mechanistic pathways controlled by stomatin and SLPs which can be employed to understand the basis of many therapeutic targets. This review briefs about the different functions of stomatin focusing mainly on the transporter proteins and carcinogenicity modulation by stomatin and SLPs.
由STOM基因编码的胃动蛋白是一种在多种物种中发现的整合膜蛋白。尽管自胃动蛋白被鉴定以来已经过去了很多年，但人们对胃动蛋白的功能了解甚少，其中胃动蛋白的同源寡聚化、翻译后和反向翻译后修饰是值得注意的方面。胃动蛋白的下调或过表达与其控制中性粒细胞脱颗粒、调节转运蛋白活性以及介导癌症转移的能力直接相关。胃动蛋白在其标志性的SPFH（胃动蛋白、抑制素、小窝蛋白和Hlfk）结构域区域与胃动蛋白样蛋白（SLPs）具有约40-80%的序列相似性。尽管据报道胃动蛋白和SLPs具有多种治疗活性，但关于它们可能的作用机制仍存在差距。因此，未来的研究应致力于研究由胃动蛋白和SLPs控制的可能的作用机制途径，这可用于理解许多治疗靶点的基础。本综述简要介绍了胃动蛋白的不同功能，主要关注转运蛋白以及胃动蛋白和SLPs对致癌性的调节。
