Miyazaki M, Arata A, Tanaka I, Ezure K
Department of Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan.
Neurosci Lett. 1998 Jun 12;249(1):61-4. doi: 10.1016/s0304-3940(98)00402-9.
The firing properties of the second-order neurons of the slowly-adapting pulmonary stretch receptors called pump neurons (P-cells), were studied in Nembutal-anesthetized, paralyzed, and artificially-ventilated rats. Extracellular recording was made from single P-cells which were monosynaptically activated by electrical stimulation of the vagal afferents and fired in phase with lung inflations. In the majority of the P-cells examined (49/52), the firing was suppressed to various extents in the inspiratory phase: in effect, their firing was accentuated at the time of the inspiratory off-switch. This issue has never been reported in cat P-cells, on which relatively rich data have been accumulated. The present results suggest that rat P-cells do not only relay information from the lung stretch receptors but also integrate the central respiratory inputs.
在戊巴比妥麻醉、麻痹并进行人工通气的大鼠中，研究了被称为泵神经元（P细胞）的慢适应性肺牵张感受器的二级神经元的放电特性。通过细胞外记录单个P细胞，这些细胞通过迷走神经传入纤维的电刺激进行单突触激活，并与肺充气同步放电。在所检查的大多数P细胞（49/52）中，放电在吸气期受到不同程度的抑制：实际上，它们的放电在吸气终止时增强。在猫的P细胞上已经积累了相对丰富的数据，但这个问题从未在猫的P细胞中报道过。目前的结果表明，大鼠P细胞不仅传递来自肺牵张感受器的信息，还整合中枢呼吸输入。
