Ezure K, Tanaka I, Miyazaki M
Department of Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan.
Neurosci Lett. 1998 Dec 11;258(1):49-52. doi: 10.1016/s0304-3940(98)00858-1.
Second-order relay neurons (referred to as rapidly adapting pulmonary stretch receptors (RARs)-cells) activated by vagal afferents originating from RARs were identified electrophysiologically in Nembutal-anesthetized, paralyzed and artificially ventilated rats. Their location in the commissural subnucleus of the nucleus tractus solitarii (NTS) and firing properties in response to lung inflations and deflations were studied in detail for the first time in the rat. Importantly, in all the RAR-cells examined, their firing was suppressed to various extent during a period from inspiration to early expiration. This means that the information from the RARs to the central nervous system is gated by the central respiratory system at the level of RAR-cells in the NTS.
在戊巴比妥麻醉、麻痹并人工通气的大鼠中，通过电生理学方法鉴定出由源自快速适应肺牵张感受器（RARs）的迷走神经传入纤维激活的二级中继神经元（称为RARs细胞）。首次在大鼠中详细研究了它们在孤束核（NTS）连合亚核中的位置以及对肺充气和放气的放电特性。重要的是，在所有检查的RARs细胞中，从吸气到呼气早期的一段时间内，它们的放电在不同程度上受到抑制。这意味着从RARs到中枢神经系统的信息在NTS中RARs细胞水平上受到中枢呼吸系统的门控。
