Campion P, Woods W G, Lemieux B
Department of Pediatrics, University of Sherbrooke Medical Center, Quebec, Canada.
Prev Med. 1998 Jul-Aug;27(4):590-6. doi: 10.1006/pmed.1998.0330.
The Quebec Screening Program for neuroblastoma was undertaken to determine if routine screening of infants for neuroblastoma would decrease the mortality rate from this cancer. All 476,603 children born in Quebec during a 5-year period (1989 to 1994) were offered this screening at ages 3 weeks and 6 months. Through various strategies, an attempt was made to attain the highest level of voluntary compliance possible.
Each screening consisted of the analysis of the catecholamine metabolites vanillylmandelic acid and homovanillic acid on a dry, urine-saturated filter paper mailed to a central laboratory by the parents. The strategies employed to optimize compliance consisted of increasing the awareness of the parents, health professionals, and the public about neuroblastoma and the screening program.
The population responded well to this public health measure, with a 91% compliance rate at 3 weeks and a 74% compliance rate at 6 months.
A well-informed population accustomed to voluntary screening for metabolic disease in infants responds well to screening for cancer.
开展魁北克神经母细胞瘤筛查项目，以确定对婴儿进行神经母细胞瘤常规筛查是否会降低该癌症的死亡率。在5年期间（1989年至1994年）出生在魁北克的所有476,603名儿童在3周龄和6月龄时都接受了此项筛查。通过各种策略，试图达到尽可能高的自愿依从水平。
每次筛查包括对儿茶酚胺代谢产物香草扁桃酸和高香草酸进行分析，样本是家长邮寄到中央实验室的干燥、尿液饱和滤纸上的尿液。为优化依从性所采用的策略包括提高家长、卫生专业人员和公众对神经母细胞瘤及筛查项目的认识。
人群对这项公共卫生措施反应良好，3周龄时的依从率为91%，6月龄时的依从率为74%。
对婴儿代谢疾病自愿筛查有所了解的人群对癌症筛查反应良好。
