Brugère-Picoux J
Laboratoire de pathologie médicale du bétail et des animaux de basse-cour, Maisons-Alfort.
Bull Acad Natl Med. 1998;182(4):823-29; discussion 830-2.
In recent years, attention and discussion have been devoted to the possible association of Mycobacterium paratuberculosis, agent of paratuberculosis in ruminants, with Crohn's disease. Both diseases, which affect young adults, are characterized by chronic granulomatous lesions, typically concentrated in the terminal ileum, and clinical signs of enteritis and weight loss. The etiology of Crohn's disease is unknown but genetic, environmental, immunological and microbiological influences, in various combinations, have been suggested. Human exposure to M. paratuberculosis may occur essentially from a fecal contamination (drinking water, milk...). This association between Crohn's disease and paratuberculosis has been shown but a causal relationship remains to be demonstrated.
近年来，反刍动物副结核病病原体副结核分枝杆菌与克罗恩病之间可能存在的关联已受到关注并引发讨论。这两种疾病均影响年轻人，其特征为慢性肉芽肿性病变，通常集中在回肠末端，伴有肠炎和体重减轻的临床症状。克罗恩病的病因尚不清楚，但有人提出，遗传、环境、免疫和微生物等多种因素以不同组合方式发挥了作用。人类接触副结核分枝杆菌主要可能源于粪便污染（饮用水、牛奶等）。克罗恩病与副结核病之间的这种关联已得到证实，但因果关系仍有待证明。
