支气管败血波氏杆菌中BrkA表达的特征分析
Characterization of BrkA expression in Bordetella bronchiseptica.
作者信息
Rambow A A, Fernandez R C, Weiss A A
机构信息
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA.
出版信息
Infect Immun. 1998 Aug;66(8):3978-80. doi: 10.1128/IAI.66.8.3978-3980.1998.
Abstract
BrkA confers resistance to killing by complement in Bordetella pertussis. Complement resistance in Bordetella bronchiseptica was examined. Four B. bronchiseptica strains possessed the brkA gene; however, only three expressed the protein. Only the strain lacking BrkA was susceptible to complement. Introduction of the B. pertussis brkA gene restored BrkA expression to this strain but did not confer resistance. brkA was mutated in the strains that naturally expressed BrkA, and loss of BrkA did not confer sensitivity to complement. As a species, B. bronchiseptica is more resistant to complement than B. pertussis, and BrkA does not mediate resistance.
摘要
BrkA赋予百日咳博德特氏菌对补体杀伤的抗性。对支气管败血博德特氏菌的补体抗性进行了检测。四株支气管败血博德特氏菌菌株含有brkA基因；然而，只有三株表达该蛋白。只有缺乏BrkA的菌株对补体敏感。引入百日咳博德特氏菌brkA基因可使该菌株恢复BrkA表达，但并未赋予抗性。在天然表达BrkA的菌株中brkA发生了突变，BrkA的缺失并未使菌株对补体敏感。作为一个物种，支气管败血博德特氏菌比百日咳博德特氏菌对补体的抗性更强，且BrkA不介导抗性。
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