Saraçlar Y, Cetinkaya F, Tuncer A, Sekerel B, Hovanec-Burns D, Unver E
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 1998 Jan-Mar;40(1):61-8.
Allergic reactions to latex products are an important health problem for health care workers and children. To investigate the prevalence of latex and latex-associated food sensitivities among hospital employees and atopic children, 61 hospital employees (44 nurses, 13 cleaning staff, 4 technicians) and 40 atopic children were evaluated by in vivo and in vitro testing methods. All subjects were also skin prick tested with common inhalant allergens and some cross-reactive food allergens to latex. In addition, all subjects were evaluated using an enzyme-linked immunometric assay for detection of specific IgE to inhalant allergens and to the known food latex cross-reactant food allergens (banana, chestnut, peanut and kiwi fruit). Latex challenges were performed in 12 history-negative and anti-latex IgE positive atopic children. Seven of the 61 hospital staff (11.4%) and four of the 40 atopic children (10%) showed skin reactivity to latex. By serologic testing, hypersensitivity to latex was found in 30 subjects, to banana in 23, to chestnut in 37, to peanut in 32 and to kiwi fruit in 22 subjects. Latex challenges were negative in all of the children who were tested. Total IgE was higher than expected in 32 subjects and 50 individuals tested positive for specific IgE to common inhalant allergens (AlaTOP). These results indicate that latex allergy may be a health problem for our hospital staff and atopic children. In vitro testing may detect latex-specific IgE in atopic children even when no history of an adverse reaction to latex is present.
乳胶制品过敏反应对医护人员和儿童来说是一个重要的健康问题。为了调查医院员工和特应性儿童中乳胶及乳胶相关食物过敏的患病率，采用体内和体外检测方法对61名医院员工（44名护士、13名清洁人员、4名技术人员）和40名特应性儿童进行了评估。所有受试者还接受了常见吸入性过敏原和一些与乳胶交叉反应的食物过敏原的皮肤点刺试验。此外，使用酶联免疫分析对所有受试者进行评估，以检测针对吸入性过敏原和已知与乳胶交叉反应的食物过敏原（香蕉、栗子、花生和猕猴桃）的特异性IgE。对12名既往史阴性且抗乳胶IgE阳性的特应性儿童进行了乳胶激发试验。61名医院工作人员中有7名（11.4%），40名特应性儿童中有4名（10%）对乳胶表现出皮肤反应性。通过血清学检测，发现30名受试者对乳胶过敏，23名对香蕉过敏，37名对栗子过敏，32名对花生过敏，22名对猕猴桃过敏。所有接受检测的儿童乳胶激发试验均为阴性。32名受试者的总IgE高于预期，50名个体针对常见吸入性过敏原（AlaTOP）的特异性IgE检测呈阳性。这些结果表明，乳胶过敏可能是我们医院工作人员和特应性儿童面临的一个健康问题。即使特应性儿童没有乳胶不良反应史，体外检测也可能检测到乳胶特异性IgE。
