Noyan A, Küçükosmanoğlu O, Yildizdaş D, Ozbarlas N, Anarat A, Anarat R
Department of Pediatric Nephrology, Cukurova University Faculty of Medicine, Adana, Turkey.
Turk J Pediatr. 1998 Jan-Mar;40(1):97-101.
Radiocontrast nephrotoxicity, which has increased in incidence with widespread use of radiological methods in medicine, is a serious complication of radiocontrast materials. In this study, we have prospectively investigated whether children with cyanotic congenital heart disease are at risk for radiocontrast nephrotoxicity with the use of a nonionic low osmolar contrast agent. Thirty-five children (17 cyanotic and 18 acyanotic patients) who underwent diagnostic cardiac catheterization were subjects of the study. The age range was from five days to 13 years. The volume of contrast material was 3.11 +/- 1.37 ml/kg in cyanotic patients and 2.67 +/- 0.86 ml/kg in acyanotic patients. Blood samples and timed urine samples were taken from all patients 24 hours before and 48 hours after cardiac catheterization. Blood urea nitrogen, creatinine, sodium, and phosphorus in serum, and creatinine and N-acetyl-beta-D-glucosamine in urine were analyzed. There was not a statistically significant difference between the values before and after angiography. As a result, we could find no evidence of radiocontrast nephrotoxicity with the use of a nonionic contrast agent in cyanotic and acyanotic patients who underwent cardiac angiography.
随着放射学方法在医学中的广泛应用，放射造影剂肾病的发病率有所增加，它是放射造影剂的一种严重并发症。在本研究中，我们前瞻性地调查了患有青紫型先天性心脏病的儿童在使用非离子低渗造影剂时是否有发生放射造影剂肾病的风险。35名接受诊断性心导管检查的儿童（17名青紫型和18名非青紫型患者）是本研究的对象。年龄范围为5天至13岁。青紫型患者的造影剂用量为3.11±1.37 ml/kg，非青紫型患者为2.67±0.86 ml/kg。在心脏导管插入术前24小时和术后48小时采集所有患者的血样和定时尿样。分析血清中的血尿素氮、肌酐、钠和磷，以及尿中的肌酐和N-乙酰-β-D-氨基葡萄糖。血管造影前后的值没有统计学上的显著差异。因此，我们没有发现接受心脏血管造影的青紫型和非青紫型患者使用非离子造影剂时有放射造影剂肾病的证据。
