Akyüz C, Emir S, Güler N, Tüker A, Büyükpamukçu M
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 1998 Jan-Mar;40(1):131-4.
We present a case of myelodysplastic syndrome (MDS) following treatment for medulloblastoma. The tumor was diagnosed at 15 years of age and managed with surgery, craniospinal radiation and a triple-drug regimen [chloroethylnitrosourea (CCNU), vincristine (VCR), procarbazine]. Fifteen months after the completion of therapy, the patient developed MDS with monosomy 5 and monosomy 7 on chromosome analysis of bone marrow cells. Two weeks later, MDS evolved into acute myeloblastic leukemia (AML). Therapy-related MDS or AML may be a complication for patients with past brain tumors. Therefore, they should be carefully followed up by regular physical examinations and complete blood counts.
我们报告一例髓母细胞瘤治疗后发生骨髓增生异常综合征（MDS）的病例。该肿瘤于15岁时被诊断出来，并接受了手术、颅脊髓放疗和三联药物方案[洛莫司汀（CCNU）、长春新碱（VCR）、丙卡巴肼]治疗。治疗结束15个月后，患者在骨髓细胞染色体分析中出现了伴有5号染色体单体和7号染色体单体的MDS。两周后，MDS演变为急性髓细胞白血病（AML）。治疗相关的MDS或AML可能是既往脑肿瘤患者的一种并发症。因此，应对他们进行定期体格检查和全血细胞计数，仔细随访。
