de la Sota M, Puche R, Rigalli A, Fernández L M, Benassati S, Boland R
Laboratorio de Biología Osea, Universidad Nacional de Rosario, Argentina.
Medicina (B Aires). 1997;57(4):417-20.
This paper reports metabolic data of 24 women and two men, 44-66 years old, ex-residents in an area of endemic fluorosis close to Bahía Blanca city. Fasting fluoremias of these subjects (0.5 to 9.2 microM) and daily urinary fluoride excretion (> 60 mumoles/day) are characteristics of zones with endemic fluorosis. Bone mineral density (BMD) at the lumbar spine (L2-4 1330 +/- 41 mg/cm2) and femoral neck (1045 +/- 10 mg/cm2) were significantly above average of normal subjects of the same age and sex. A significant correlation was observed between the daily excretion of fluoride and BMD L2-4 (r = 0.43, P < 0.05). The Area Under the Curve of insulin during a standard glucose tolerance test showed an inverse relationship with fluoremia. This observation coincides with experiments published elsewhere indicating that fluoride intake at concentrations 5 microM or greater, inhibits the secretion of insulin.
本文报告了24名女性和2名男性的代谢数据，这些人年龄在44至66岁之间，曾是布兰卡湾市附近地方性氟中毒地区的居民。这些受试者的空腹血氟水平（0.5至9.2微摩尔/升）和每日尿氟排泄量（>60微摩尔/天）是地方性氟中毒地区的特征。腰椎（L2 - 4，1330±41毫克/平方厘米）和股骨颈（1045±10毫克/平方厘米）的骨矿物质密度显著高于同年龄和性别的正常受试者平均水平。氟的每日排泄量与L2 - 4的骨矿物质密度之间存在显著相关性（r = 0.43，P < 0.05）。在标准葡萄糖耐量试验期间，胰岛素曲线下面积与血氟水平呈负相关。这一观察结果与其他地方发表的实验结果一致，表明氟摄入量达到5微摩尔/升或更高浓度时，会抑制胰岛素分泌。
