Matrougui K, Schiavi P, Guez D, Henrion D
Institut National de la Santé et de la Recherche Médicale (INSERM) U 141, IFR6 Circulation Lariboisière, Université Paris VII, France.
Hypertension. 1998 Jul;32(1):176-9. doi: 10.1161/01.hyp.32.1.176.
High sodium intake has been associated with a higher blood pressure level. Resistance arteries are the main determinants of blood pressure. They are largely regulated by pressure (tensile stress)-induced tone (myogenic tone, MT) and by flow (shear stress)-induced dilation (FD). Thus, we studied the effect of NaCl (8%) intake for 8 weeks on FD and MT in mesenteric resistance arteries of spontaneously hypertensive rats. Arteries were cannulated and mounted in an arteriograph. Intraluminal diameter was measured continuously. High NaCl intake increased mean arterial pressure (186+/-5 to 217+/-6 mm Hg, P<0.01). Passive arterial diameter ranged from 112+/-6 to 185+/-9 microm (pressure from 25 to 125 mmHg, no effect of NaCl). MT developed in response to pressure (tone from 89+/-1% to 83+/-3% of passive diameter, 25 to 125 mm Hg). High NaCl intake significantly decreased MT (89+/-1% versus 83+/-3% of passive diameter when pressure was 125 mm Hg, P<0.023). High NaCl intake also decreased FD (6.5+/-0.8 versus 10+/-1.3 microm dilation under a pressure of 100 mm Hg and a flow rate of 160 microL/min, P<0.012). Thus, high salt intake decreased both flow (shear stress)-induced dilation and pressure (tensile stress)-induced tone in mesenteric resistance arteries. These findings might reflect attenuation by NaCl of flow and pressure mechanosensor processes.
高钠摄入与较高的血压水平相关。阻力动脉是血压的主要决定因素。它们在很大程度上受压力（拉伸应力）诱导的张力（肌源性张力，MT）和血流（剪切应力）诱导的扩张（FD）调节。因此，我们研究了8周8%氯化钠摄入对自发性高血压大鼠肠系膜阻力动脉中FD和MT的影响。将动脉插管并安装在血管造影仪中。连续测量管腔内直径。高氯化钠摄入使平均动脉压升高（从186±5 mmHg升至217±6 mmHg，P<0.01）。被动动脉直径范围为112±6至185±9微米（压力从25至125 mmHg，氯化钠无影响）。MT随压力产生（张力从被动直径的89±1%至83±3%，25至125 mmHg）。高氯化钠摄入显著降低MT（压力为125 mmHg时，被动直径的89±1%对83±3%，P<0.023）。高氯化钠摄入也降低了FD（在100 mmHg压力和160微升/分钟流速下，扩张为6.5±0.8对10±1.3微米，P<0.012）。因此，高盐摄入降低了肠系膜阻力动脉中血流（剪切应力）诱导的扩张和压力（拉伸应力）诱导的张力。这些发现可能反映了氯化钠对血流和压力机械传感器过程的减弱作用。
