Lee R S, Koob G F, Henriksen S J
Department of Neuropharmacology, The Scripps Research Institute, Blake Building CVN-13, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA.
Brain Res. 1998 Jul 20;799(2):317-22. doi: 10.1016/s0006-8993(98)00477-6.
To establish a physiological correlate of goal-directed and reward-seeking non-operant behaviors, we studied the electrophysiological activity of NAcc neurons in unrestrained, naive Sprague-Dawley rats. Our results showed an inhibitory response in 21% (7/34) of the recorded NAcc neurons during spontaneous nosepoking behavior and in 16% (4/25) of the NAcc neurons when rats were fed with a favorite novel food morsel (popcorn). These data suggest that a subgroup of NAcc neurons is actively modulated during motivated behavior and during consummatory events resulting in a suppression of neuronal activity.
为了建立目标导向和奖励寻求非操作性行为的生理关联，我们研究了自由活动、未经过训练的斯普拉格-道利大鼠伏隔核神经元的电生理活动。我们的结果显示，在自发的鼻触行为中，记录到的伏隔核神经元中有21%（7/34）出现抑制反应，而在给大鼠喂食喜爱的新奇食物（爆米花）时，伏隔核神经元中有16%（4/25）出现抑制反应。这些数据表明，在动机行为和完成事件期间，伏隔核神经元的一个亚群会被积极调节，从而导致神经元活动受到抑制。
