Horton S L, Hashimoto K, Toi Y, Miner J E, Mehregan D, Fligiel A, Savoy L B, Aronson P
Wayne State University, Detroit, Michigan, USA.
J Dermatol. 1998 Jun;25(6):353-61. doi: 10.1111/j.1346-8138.1998.tb02414.x.
Spiny keratoderma is a dermatosis consisting of multiple projections located on the palms and soles, with a distinct histology characteristic of a parakeratotic column above a hypogranular epidermis. We report six cases discovered within a year and review the present literature on spiny keratoderma. The average age of the patients was 57 years. Fifty-seven percent of the patients were male and forty-three percent were female. The duration of lesions ranged from 4 months to 40 years. Symptoms were variable, however, lesions were often unnoticed by the patient. The location of the lesions involved the palms and soles or the palms alone. Past medical history was significant for hypertension and hyperlipidemia treated with HMG-CoA reductase inhibitors. Lesions often occurred in patients involved in manual labor. Spiny keratoderma is a relatively common under-reported dermatosis found most often in older patients with history of manual labor and is possibly related to treatment with HMG-CoA reductase inhibitors.
棘状角化病是一种皮肤病，表现为手掌和足底出现多个凸起，其组织学特征明显，即在颗粒层减少的表皮上方有不全角化柱。我们报告了一年内发现的6例病例，并回顾了目前关于棘状角化病的文献。患者的平均年龄为57岁。57%的患者为男性，43%为女性。皮损持续时间从4个月到40年不等。症状各不相同，然而，患者往往未注意到皮损。皮损部位累及手掌和足底或仅累及手掌。既往病史中，高血压和高脂血症患者接受HMG-CoA还原酶抑制剂治疗的情况较为显著。皮损常发生于从事体力劳动的患者。棘状角化病是一种相对常见但报告不足的皮肤病，多见于有体力劳动史的老年患者，可能与HMG-CoA还原酶抑制剂治疗有关。
