通过糖烯重排制备改性糖基甘油衍生物

Preparation of modified glycosyl glycerol derivatives by glycal rearrangement.

作者信息

Wieczorek E, Thiem J

机构信息

Institut für Organische Chemie, Universität Hamburg, Germany.

出版信息

Carbohydr Res. 1998 Feb;307(3-4):263-70. doi: 10.1016/s0008-6215(98)00038-x.

DOI:10.1016/s0008-6215(98)00038-x

PMID:9675367

Abstract

By Lewis acid catalysed allylic rearrangement reactions of various glycals with glycerol derivatives 2,3-unsaturated mono- and disaccharide glycosyl glycerol derivatives were obtained in good yields. A triglycosyl glycerol was successfully synthesized in a straightforward three step way from 3,4,6-tri-O-acetyl-1,5-anhydro-2-deoxy-D-arabino-hex-1-enitol.

摘要

通过各种缩水甘油醛与甘油衍生物的路易斯酸催化烯丙基重排反应，以良好的产率获得了2,3-不饱和单糖和二糖糖基甘油衍生物。从3,4,6-三-O-乙酰基-1,5-脱水-2-脱氧-D-阿拉伯-己-1-烯糖醇出发，通过直接的三步法成功合成了三糖基甘油。