N-乙酰半胱氨酸对C型病毒慢性肝炎患者淋巴细胞谷胱甘肽及干扰素治疗反应的影响

Effect of N-acetyl-cysteine on lymphomonocyte glutathione and response to interferon treatment in C-virus chronic hepatitis.

作者信息

Cimino L, Belisario M A, Intrieri M, D'Ascoli B, Sacchetti L, Salvatore F, Budillon G

机构信息

Chair of Gastroenterology, School of Medicine, University Federico II, Naples, Italy.

出版信息

Ital J Gastroenterol Hepatol. 1998 Apr;30(2):189-93.

PMID:9675657

Abstract

BACKGROUND/AIM: Much controversy exists concerning effect of N-acetyl-cysteine, a precursor of glutathione, on the response to interferon treatment in patients with C-virus chronic hepatitis. The aim of this study was to evaluate the efficacy of interferon therapy with and without oral N-acetyl-cysteine. We also measured glutathione concentrations in lymphomonocytes of 25 patients with chronic C-virus hepatitis before and after interferon treatment and correlated the results with treatment response.

METHODS

Glutathione was extracted from lymphomonocytes and measured with a modified high performance liquid chromatographic method in the 25 hepatitis patients and 12 healthy controls.

RESULTS/CONCLUSIONS: 1) Hepatitis patients and controls had similar basal concentrations of lymphomonocytic glutathione; 2) neither interferon nor N-acetyl-cysteine significantly affected glutathione concentrations in patients; and 3) N-acetyl-cysteine did not affect response to interferon.

摘要

背景/目的：关于谷胱甘肽的前体N - 乙酰半胱氨酸对丙型病毒性慢性肝炎患者干扰素治疗反应的影响，存在诸多争议。本研究的目的是评估联合或不联合口服N - 乙酰半胱氨酸的干扰素治疗效果。我们还测量了25例慢性丙型病毒性肝炎患者在干扰素治疗前后淋巴细胞内的谷胱甘肽浓度，并将结果与治疗反应相关联。