Kim M, Otsuka M, Shimamura E, Arakawa N
Department of Nutrition and Food Science, Ochanomizu University, Tokyo, Japan.
J Nutr Sci Vitaminol (Tokyo). 1998 Apr;44(2):217-24. doi: 10.3177/jnsv.44.217.
In order to elucidate the effect of L-ascorbic acid (AsA) on the formation of pyridinoline, a mature crosslink of collagen, its content in cartilage collagen of guinea pigs supplemented with and without AsA in the growing process (4-8 weeks of age) and in the period of maturity (10-14 weeks of age) was examined. The AsA-deficient animals, for four weeks during the growing process, had a significantly higher content of pyridinoline in their collagen than the AsA-supplemented group, indicating that the depletion of AsA induced increasing contents of pyridinoline. On the other hand, in the period of maturity, the pyridinoline content in the collagen decreased with age, whereas no difference between AsA-deficient and -supplemented groups was observed. Based on these results, it is assumed that AsA affects the formation of pyridinoline, especially in the growing period.
为了阐明L-抗坏血酸（AsA）对吡啶啉（一种成熟的胶原蛋白交联物）形成的影响，研究了豚鼠在生长过程（4 - 8周龄）和成熟阶段（10 - 14周龄）补充和未补充AsA时软骨胶原蛋白中AsA的含量。在生长过程中缺乏AsA四周的动物，其胶原蛋白中吡啶啉的含量显著高于补充AsA的组，这表明AsA的消耗会导致吡啶啉含量增加。另一方面，在成熟阶段，胶原蛋白中的吡啶啉含量随年龄下降，而未观察到AsA缺乏组和补充组之间的差异。基于这些结果，推测AsA影响吡啶啉的形成，尤其是在生长时期。
