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[阿昔单抗推注溶解急性支架血栓形成]

[Dissolution of acute stent thrombosis by abciximab bolus].

作者信息

Russo G, Nicosia A, Tamburino C, Mammana C, Galassi A R, Monaco A, Grassi R, Calvi V, Giuffrida G

机构信息

Istituto di Cardiologia, Università degli Studi, Catania.

出版信息

Cardiologia. 1998 Jun;43(6):631-4.

PMID:9675963
Abstract

Abciximab, REOPRO, a potent inhibitor of platelet aggregation via glycoprotein IIb/IIIa inhibition, has shown to be effective in the prevention of short and long-term complications of percutaneous coronary interventions. Very few reports on the role of this drug in the setting of acute stent thrombosis have been published. We report 1 case of the effectiveness of REOPRO in the complete lysis of stent thrombus with reperfusion of the coronary vessel and its collaterals. This case suggests an important role of platelets in the setting of acute stent thrombosis and a thrombolytic effect of REOPRO.

摘要

阿昔单抗(商品名:REOPRO)是一种通过抑制糖蛋白IIb/IIIa来强力抑制血小板聚集的药物,已证明其在预防经皮冠状动脉介入治疗的短期和长期并发症方面有效。关于这种药物在急性支架血栓形成情况下作用的报道极少。我们报告1例阿昔单抗(REOPRO)在完全溶解支架血栓并使冠状动脉及其侧支血管再灌注方面有效的病例。该病例提示血小板在急性支架血栓形成过程中起重要作用,且阿昔单抗(REOPRO)具有溶栓作用。

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