Di Mattéo J, Vacheron A, Heulin A, Meeus L, Di Mattéo G, Gilles R, Delage F, de Ratuld A
Arch Mal Coeur Vaiss. 1978 Apr;71(4):447-52.
The cardiac complications of radiotherapy have been reviewed in the light of 46 case histories collected from 16 treatment centres in France. They are usually found after radiotherapy for Hodgkin's disease and carcinoma of the breast. Although histologically there may be diffuse fibrosis involving the endocardium, myocardium and pericardium, it is pericarditis which is the usual clinical feature. It often occurs late, and takes many forms. The dry constrictive fibrous type of pericarditis is the most severe because of the amount of myocardial fibrosis usually associated with it. It is rare for there to be clinical features of myocardial fibrosis, and if present they are variable: isolated disorders of repolarisation or of conduction, or true cardiomyopathies. Lesions of the coronary arteries are exceptionally rare after radiotherapy, and involve fibrosis of the intima or atherosclerosis.
根据从法国16个治疗中心收集的46例病史，对放疗的心脏并发症进行了综述。这些并发症通常在霍奇金病和乳腺癌放疗后出现。尽管组织学上可能存在累及心内膜、心肌和心包的弥漫性纤维化，但心包炎是常见的临床特征。它常发生在后期，且形式多样。干性缩窄性纤维性心包炎最为严重，因为通常与之相关的心肌纤维化程度较高。心肌纤维化的临床特征很少见，若有则表现各异：孤立的复极或传导障碍，或真正的心肌病。放疗后冠状动脉病变极为罕见，包括内膜纤维化或动脉粥样硬化。
