脊椎动物组织和体液中游离D-氨基酸的分布

Distribution of free D-amino acids in tissues and body fluids of vertebrates.

作者信息

Imai K, Fukushima T, Santa T, Homma H, Huang Y, Sakai K, Kato M

机构信息

Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.

出版信息

Enantiomer. 1997;2(3-4):143-5.

PMID:9676266

Abstract

Reports on the distribution, metabolism and origins of free D-amino acids in vertebrate tissues and body fluids are reviewed. The transient emergence of D-aspartic acid during the development of brain and peripheral organs or early stages of life is reported. D-Serine in brain is postulated to be a potentiator for the N-methyl-D-aspartate (NMDA) receptor. Some D-amino acid concentrations in human serum, such as D-Ser and D-Ala, are suggested to correlate with damage to renal function.

摘要

本文综述了关于脊椎动物组织和体液中游离D-氨基酸的分布、代谢及来源的报告。据报道，在大脑和外周器官发育过程或生命早期阶段会短暂出现D-天冬氨酸。大脑中的D-丝氨酸被认为是N-甲基-D-天冬氨酸（NMDA）受体的增强剂。有人提出，人血清中的一些D-氨基酸浓度，如D-丝氨酸和D-丙氨酸，与肾功能损害有关。