Carroll G L, Howe L B, Slater M R, Haughn L, Martinez E A, Hartsfield S M, Matthews N S
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843-4474, USA.
J Am Vet Med Assoc. 1998 Jul 15;213(2):246-50.
To evaluate adequacy of analgesia provided by postoperative administration of butorphanol to cats undergoing onychectomy.
Randomized controlled trial.
63 cats undergoing elective onychectomy.
Cats were randomly assigned to a treatment (n = 42) or control group (21). Cats in the treatment group were given butorphanol parenterally immediately and 4 hours after surgery and orally for 2 days after surgery. Rectal temperature, heart rate, and respiratory rate were recorded and scores were assigned for temperament, recovery, sedation, analgesia, and lameness for the first 24 hours after surgery. Owners provided scores for appetite, personality, and lameness the first and second days after discharge from the hospital.
Heart rate, respiratory rate, rectal temperature, and temperament and sedation scores were not significantly different between groups at any evaluation time. Recovery scores were significantly better for butorphanol-treated than for control-group cats 10 minutes after extubation. Analgesia scores were significantly better for butorphanol-treated than for control-group cats between 5 and 24 hours after surgery. Fewer butorphanol-treated than control-group cats were lame at the time of discharge from the hospital. The first day after discharge, owners reported that percentages of butorphanol-treated cats that ate normally, acted normally, and had only mild or no lameness were significantly higher than percentages of control-group cats that did. Significant differences between groups were not detected the second day after discharge.
Results suggest that for cats undergoing onychectomy, administration of butorphanol the day of surgery and the first full day after surgery provides effective analgesia and improves recovery, appetite, and gait.
评估布托啡诺术后给药对接受爪切除术的猫的镇痛效果。
随机对照试验。
63只接受择期爪切除术的猫。
将猫随机分为治疗组（n = 42）或对照组（21只）。治疗组的猫在术后立即和术后4小时接受布托啡诺非肠道给药，并在术后2天口服给药。记录直肠温度、心率和呼吸频率，并在术后头24小时对性情、恢复情况、镇静程度、镇痛效果和跛行情况进行评分。主人在猫出院后的第一天和第二天对食欲、性格和跛行情况进行评分。
在任何评估时间，两组之间的心率、呼吸频率、直肠温度以及性情和镇静评分均无显著差异。拔管后10分钟，布托啡诺治疗组的恢复评分明显优于对照组猫。术后5至24小时，布托啡诺治疗组的镇痛评分明显优于对照组猫。出院时，布托啡诺治疗组跛行的猫比对照组少。出院后的第一天，主人报告说，布托啡诺治疗组正常进食、行为正常且仅有轻度跛行或无跛行的猫的百分比明显高于对照组。出院后第二天未发现两组之间有显著差异。
结果表明，对于接受爪切除术的猫，在手术当天和术后第一个整天给予布托啡诺可提供有效的镇痛效果，并改善恢复情况、食欲和步态。
