Carpentier N, Bertin P, Marquet P, Sabot C, Bonnet C, Debord J, Lachâtre G, Trèves R
Department of Rheumatology, Dupuytren University Hospital, Limoges, France.
J Rheumatol. 1998 Jul;25(7):1270-5.
To determine the optimal time to administer methotrexate (MTX) in rheumatoid arthritis (RA).
In a crossover study 23 patients were administered MTX intramuscularly at either 10 AM or 6 PM. A 2 week interval separated the 2 injections. MTX concentrations were measured using a fluorescence polarization immunoassay. Pharmacokinetic variables were estimated using a Bayesian approach. The morning and evening schedules were compared using analysis of variance to determine the optimal time of injection.
No statistical difference was found in the pharmacokinetics of MTX according to hour of injection. A difference in the creatinine clearance, however, was observed in the samples obtained at noon and 8 PM, but clearance of MTX was unchanged.
Pharmacokinetic variables suggest that MTX can be administered either in the morning (10 AM) or evening (6 PM) in the treatment of RA.
确定类风湿关节炎（RA）中使用甲氨蝶呤（MTX）的最佳给药时间。
在一项交叉研究中，23名患者分别于上午10点或下午6点接受MTX肌肉注射。两次注射间隔2周。使用荧光偏振免疫分析法测量MTX浓度。采用贝叶斯方法估计药代动力学变量。使用方差分析比较上午和晚上的给药方案，以确定最佳注射时间。
根据注射时间，MTX的药代动力学未发现统计学差异。然而，在中午和晚上8点采集的样本中观察到肌酐清除率存在差异，但MTX的清除率未改变。
药代动力学变量表明，在治疗RA时，MTX既可以在上午（10点）给药，也可以在晚上（6点）给药。
