Takahashi K, Kumakura S, Ishikura H, Murakawa Y, Yamauchi Y, Kobayashi S
Third Division of Internal Medicine, Shimane Medical University.
Intern Med. 1998 Jun;37(6):550-3. doi: 10.2169/internalmedicine.37.550.
A patient with systemic lupus erythematosus (SLE) developed reactive hemophagocytosis. This case did not show any underlying diseases such as infection or malignancy other than SLE itself. The mechanisms inducing hemophagocytosis in SLE seem to be heterogeneous and remain to be elucidated. Although an immune complex-mediated mechanism in cases with acute lupus hemophagocytic syndrome has been proposed, we suggest the possible involvement of IL-1beta as the pathogenesis of our case.
一名系统性红斑狼疮（SLE）患者发生了反应性噬血细胞增多症。该病例除SLE本身外，未显示出任何潜在疾病，如感染或恶性肿瘤。SLE中诱导噬血细胞增多症的机制似乎是异质性的，仍有待阐明。尽管有人提出急性狼疮噬血细胞综合征病例存在免疫复合物介导的机制，但我们认为白细胞介素-1β可能参与了我们病例的发病机制。
