Peleg D, Yankowitz J
Department of Obstetrics and Gynecology, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City 52242-1080, USA.
J Med Genet. 1998 Jul;35(7):554-7. doi: 10.1136/jmg.35.7.554.
The association of choroid plexus cysts with fetal aneuploidy, particularly trisomy 18, was first noted in 1986. Through the years there have been numerous reports on this subject, but no consensus has been reached with regard to chromosomal risk. In this review, we attempt to summarise published reports on second trimester choroid plexus cysts, with an emphasis on the strengths and weaknesses of each report. Based on these reports, additional malformations are a significant risk factor for aneuploidy and an indication for determination of fetal karyotype. The management of isolated choroid plexus cysts remains controversial.
脉络丛囊肿与胎儿非整倍体，尤其是18三体的关联最早于1986年被发现。多年来，关于这一主题已有大量报道，但在染色体风险方面尚未达成共识。在本综述中，我们试图总结关于孕中期脉络丛囊肿的已发表报告，重点关注每份报告的优缺点。基于这些报告，其他畸形是胎儿非整倍体的重要风险因素及胎儿核型测定的指征。孤立性脉络丛囊肿的处理仍存在争议。
