人胰腺全切除术后的血浆胰高血糖素

Plasma glucagon after total resection of the pancreas in man.

作者信息

Miyata M, Yamamoyo T, Yamaguchi M, Nakao K, Yoshida T

出版信息

Proc Soc Exp Biol Med. 1976 Sep;152(4):540-3. doi: 10.3181/00379727-152-39435.

Abstract

Serial measurements of plasma "true glucagon" (PG) and of glucagon-like immunoreactive materials (GLI) were carried out during and after total resection of the pancreas in a 62-year-old man with calcified pancreatitis. The postoperative course of this patient was uneventful and diabetes was well controlled. PG disappeared from the blood within 30 min after resection of the pancreas. In spite of the evidence that no pancreatic tissue was present in the abdomen, PG was detected again in the blood from 18 hr after total pancreatectomy until the ninth postoperative day. However, plasma PG did not rise following infusion of arginine during the fourteenth postoperative week. After an initial decrease, plasma GLI rose abruptly on the second postoperative day and remained elevated thereafter. The fluctuations of plasma PG and GLI were not parallel.

摘要

对一名患有钙化性胰腺炎的62岁男性患者，在胰腺全切除术中及术后进行了血浆“真胰高血糖素”（PG）和胰高血糖素样免疫反应物质（GLI）的系列测量。该患者术后过程顺利，糖尿病得到良好控制。胰腺切除术后30分钟内，PG从血液中消失。尽管有证据表明腹部已无胰腺组织，但在全胰切除术后18小时直至术后第9天，血液中再次检测到PG。然而，术后第14周输注精氨酸后，血浆PG并未升高。术后第一天血浆GLI在最初下降后突然升高，此后一直保持升高。血浆PG和GLI的波动并不平行。