Kobayashi K, Sumi S, Kidouchi K, Mizuno I, Mohri N, Fukui T, Akamo Y, Takeyama H, Manabe T
First Dept. of Surgery, Nagoya City University Medical School.
Gan To Kagaku Ryoho. 1998 Jul;25(8):1217-9.
We analyzed the pyrimidine metabolite in the urine of a patient with severe mucositis and hand and foot syndrome, who was administered 5-fluorouracil for recurrence of gastric cancer. From our analysis, it was suggested that the patient had decreased dihydropyrimidine dehydrogenase activity. Dihydropyrimidine dehydrogenase activity is usually measured in peripheral blood mononuclear cells, but this time it was estimated from the analysis of uracil, dihydrouracil, thymine, and dihydrothymine in the urine. We concluded that urinary analysis of the pyrimidine metabolism is effective as screening for the prediction and prevention of 5-fluorouracil toxicity.
我们分析了一名患有严重粘膜炎和手足综合征的胃癌复发患者尿液中的嘧啶代谢产物，该患者接受了5-氟尿嘧啶治疗。通过我们的分析，提示该患者二氢嘧啶脱氢酶活性降低。二氢嘧啶脱氢酶活性通常在外周血单核细胞中测量，但此次是通过对尿液中的尿嘧啶、二氢尿嘧啶、胸腺嘧啶和二氢胸腺嘧啶进行分析来估计的。我们得出结论，嘧啶代谢的尿液分析作为预测和预防5-氟尿嘧啶毒性的筛查方法是有效的。
