2-脱氧-D-葡萄糖四乙酸酯对葡萄糖诱导的胰岛素释放的双重作用。

Dual effect of 2-deoxy-D-glucose tetraacetate upon glucose-induced insulin release.

作者信息

Malaisse W J, Flores L E, Kadiata M M

机构信息

Laboratory of Experimental Medicine, Brussels Free University, Belgium.

出版信息

Biochem Mol Biol Int. 1998 Jul;45(3):429-34. doi: 10.1080/15216549800202812.

DOI:10.1080/15216549800202812

PMID:9679643

Abstract

The effect of 2-deoxy-D-glucose tetraacetate upon glucose-stimulated insulin release was explored in pancreatic islets from either normal or hereditary diabetic rats. At a high concentration (10 mM), it decreased the secretory response to D-glucose, such an inhibitory effect being more marked in the case of the alpha- than beta-anomer of the ester. At lower concentrations (0.19 to 1.7 mM), however, 2-deoxy-D-glucose tetraacetate augmented insulin secretion evoked by 8.3 mM D-glucose, with again a preference for the alpha-anomer of the ester. In relative terms, such an enhancing action was more marked in Goto-Kakizaki than normal rats. Hence, it is proposed that selected esters of non-nutrient carbohydrates could be used as insulinotropic tools in the treatment of non-insulin-dependent diabetes mellitus.

摘要

在正常或遗传性糖尿病大鼠的胰岛中，研究了四乙酰基-2-脱氧-D-葡萄糖对葡萄糖刺激的胰岛素释放的影响。在高浓度（10 mM）时，它降低了对D-葡萄糖的分泌反应，这种抑制作用在酯的α-异头物比β-异头物的情况下更为明显。然而，在较低浓度（0.19至1.7 mM）时，四乙酰基-2-脱氧-D-葡萄糖增强了8.3 mM D-葡萄糖引起的胰岛素分泌，同样更倾向于酯的α-异头物。相对而言，这种增强作用在五尾-高崎大鼠中比正常大鼠更明显。因此，有人提出，非营养性碳水化合物的特定酯类可作为治疗非胰岛素依赖型糖尿病的促胰岛素分泌工具。