Klemperer J D, Wang J, Hartman B J, Stubenbord W T
Department of Surgery, New York Hospital-Cornell University Medical Center, New York 10021, USA.
Transplantation. 1998 Jul 15;66(1):118-20. doi: 10.1097/00007890-199807150-00019.
Tuberculosis is a recognized complication following renal transplantation. Patients with autosomal dominant polycystic kidney disease are increasingly being offered renal transplantation as an alternative to chronic hemodialysis. These patients are uniquely susceptible to serious upper urinary tract infections that are associated with significant morbidity and mortality. While involvement with gram-negative organisms is well described, mycobacterial infection of native polycystic kidneys after transplantation has not been addressed.
A case report of a renal transplant recipient who suffered an isolated Mycobacterium tuberculosis infection of a native polycystic kidney and a literature review.
Despite appropriate drug therapy, the infection proved refractory, and the patient required nephrectomy.
Mycobacterial tuberculosis, though not common, must be recognized as a potential source of infection of native polycystic kidneys in immunocompromised transplant recipients. Similar to the pattern observed with more common pathogens, these infections may be difficult to eradicate with standard antimicrobial drug regimens.
结核病是肾移植后公认的并发症。常染色体显性多囊肾病患者越来越多地接受肾移植，作为慢性血液透析的替代方案。这些患者特别容易发生严重的上尿路感染，且与显著的发病率和死亡率相关。虽然革兰氏阴性菌感染已有充分描述，但移植后原生多囊肾的分枝杆菌感染尚未得到探讨。
报告一例肾移植受者原生多囊肾发生孤立性结核分枝杆菌感染的病例，并进行文献复习。
尽管采用了适当的药物治疗，感染仍难以控制，患者需要接受肾切除术。
分枝杆菌性结核虽不常见，但必须认识到它是免疫功能低下的移植受者原生多囊肾感染的潜在来源。与更常见病原体的感染模式相似，这些感染可能难以用标准抗菌药物方案根除。
