Alonso M L, Rubiol E, Mateu R, Estivill C, Bellido M, Balmaña J, Nomdedéu J F
Department of Hematology, Hospital de la Santa Creu i Sant Pau, Secció de Marcadors, Barcelona, Spain.
Leuk Res. 1998 Jul;22(7):649-53. doi: 10.1016/s0145-2126(98)00009-5.
In the present report we analyzed the immunophenotype of the neoplastic cells in a case of primary plasma cell leukemia (PCL). We performed simultaneous analysis of bone marrow and peripheral blood samples to investigate minor phenotypic variations that could explain the tendency of a population to leave medullary compartments. No major differences were observed between the two populations. The phenotype of the malignant clone was: CD38+, CD138+, CD19-, CD56+, CD117-, CD33+, CD44 , CD49e , cCD79a+ with positive cytoplasmic stain for kappa and IgG. Our findings expands the potential uses of cCD79a to cases of PCL with atypical morphology.
在本报告中，我们分析了一例原发性浆细胞白血病（PCL）中肿瘤细胞的免疫表型。我们同时对骨髓和外周血样本进行分析，以研究可能解释细胞群体离开髓腔倾向的微小表型变化。在这两个细胞群体之间未观察到重大差异。恶性克隆的表型为：CD38+、CD138+、CD19-、CD56+、CD117-、CD33+、CD44-、CD49e-、胞质cCD79a+，kappa和IgG呈阳性胞质染色。我们的研究结果扩展了cCD79a在具有非典型形态的PCL病例中的潜在应用。
