细胞外钙离子对1α型代谢型谷氨酸受体介导信号传导的调节作用。
A modulatory effect of extracellular Ca2+ on type 1alpha metabotropic glutamate receptor-mediated signalling.
作者信息
Saunders R, Nahorski S R, Challiss R A
机构信息
Department of Cell Physiology and Pharmacology, University of Leicester, UK.
出版信息
Neuropharmacology. 1998;37(2):273-6. doi: 10.1016/s0028-3908(98)00027-6.
Increasing [Ca2+]e from 1.3 4 mM had little effect on basal phospholipase C activity in baby hamster kidney (BHK) cells stably expressing either type 1alpha metabotropic glutamate (mGlu1alpha) or M3-muscarinic (m3) receptors, but enhanced agonist-stimulated phosphoinositide hydrolysis in BHK-mGlu1alpha, but not BHK-m3 cells, demonstrating that Ca2+(e) selectively modulates phosphoinositide signalling stimulated by this receptor subtype.
将细胞外钙离子浓度（[Ca2+]e）从1.3毫摩尔/升提高到4毫摩尔/升，对稳定表达1α型代谢型谷氨酸受体（mGlu1α）或M3型毒蕈碱受体（m3）的叙利亚仓鼠肾（BHK）细胞的基础磷脂酶C活性影响甚微，但增强了激动剂刺激的BHK-mGlu1α细胞中的磷酸肌醇水解，而对BHK-m3细胞无此作用，这表明细胞外钙离子（Ca2+(e)）选择性地调节由该受体亚型刺激的磷酸肌醇信号传导。
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