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[外科肝脏病学:肝移植与广泛肝切除术]

[Surgical hepatology: liver transplantation and extensive resections].

作者信息

Got'e S V

出版信息

Khirurgiia (Mosk). 1998(6):33-7.

PMID:9680801
Abstract

During 7 years (from 1990 until now) the only in Russia program of transplantation of the liver is under way in RCS RAMS. Up to now the experience has been accumulated of 24 transplantations in 23 patients, including 1 retransplantation and 6 transplantations from alive relative donor. Indications for the operation were incurable diseases of the liver with fatal prognosis including unresectable primary focal diseases. Long-term survival of the recipients in the last followed up series was obtained in 80% of cases. The longest survival reached 7 years. The quality of life of the recipients is quite satisfactory, 2 patients gave birth to healthy children. At the same time at the background of extreme deficiency of donor organs mortality rate of potential recipients during "waiting" period made up to 60.4%. Parallel development of resectional surgery of the liver made it possible to perform 49 extensive and maximally spacious resections with good results (early postoperative lethality--4.1%, actuarial 5 year survival rate of these patients--64%). Accumulated experience was a basement for the development of program for transplantation of a fragment of the liver from living relative donor.

摘要

在7年期间(从1990年至今),俄罗斯医学科学院肝脏移植项目是俄罗斯唯一正在开展的项目。截至目前,已积累了23例患者24次移植的经验,其中包括1例再次移植和6例来自活体亲属供体的移植。手术适应症为预后致命的肝脏不治之症,包括不可切除的原发性局灶性疾病。在最后随访系列中,80%的受者获得了长期生存。最长生存期达7年。受者的生活质量相当令人满意,2名患者生育了健康的孩子。与此同时,在供体器官极度短缺的背景下,潜在受者在“等待”期间的死亡率高达60.4%。肝脏切除手术的同步发展使得49例广泛且最大程度的宽敞切除得以进行,效果良好(术后早期死亡率为4.1%,这些患者的实际5年生存率为64%)。积累的经验为开展活体亲属供体肝段移植项目奠定了基础。

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