Kubesová H, Penka M, Král Z, Adam Z, Vásová I, Tomíska M, Vorlícek J
Department of Internal Medicine, Masaryk University Hospital, Brno, Czech Republic.
Acta Med Austriaca. 1998;25(2):57-60.
Mucositis is a common complication following chemotherapy. Clinical findings similar to herpetic infection are observed in some patients. Acyclovir administered in addition to empirical, antibiotic treatment improves the course of mucositis, and can also bring down the temperature. The aim of our study was to define the etiological influence of herpetic infection on the course of febrile neutropenia in patients with mucositis. A total of 34 patients with febrile neutropenia were divided into 2 groups: 15 with typical herpetic eruption, and 19 with non-specific mucositis. Both groups received 5-10 mg/kg acyclovir every eight hours together with empiric antibiotic treatment. The effect of acyclovir was studied, and results compared in the two patient groups. Body temperatures decreased in both groups, clinical symptoms, however, disappeared more slowly in the group with non-specific mucositis. The beneficial effect of acyclovir treatment was particularly well expressed in seropositive patients. In this group of patients, herpetic infections may recur under further chemotherapy. Thus, it would be useful to administer acyclovir to them prophylactically during risk periods.
口腔黏膜炎是化疗后常见的并发症。部分患者会出现类似疱疹感染的临床表现。在经验性抗生素治疗的基础上加用阿昔洛韦可改善口腔黏膜炎的病程，还能降低体温。我们研究的目的是确定疱疹感染对口腔黏膜炎患者发热性中性粒细胞减少症病程的病因学影响。总共34例发热性中性粒细胞减少症患者被分为2组：15例有典型疱疹疹出，19例有非特异性口腔黏膜炎。两组均每8小时接受5 - 10mg/kg阿昔洛韦治疗并同时进行经验性抗生素治疗。研究了阿昔洛韦的疗效，并在两组患者中比较结果。两组患者体温均下降，但非特异性口腔黏膜炎组临床症状消失得更慢。阿昔洛韦治疗的有益效果在血清学阳性患者中表现尤为明显。在这组患者中，进一步化疗期间疱疹感染可能复发。因此，在危险期对他们预防性给予阿昔洛韦是有益的。
