Higgins G, Hughes A, Dutton J, Roberts N B
Department of Clinical Chemistry, Royal Liverpool University Hospital, UK.
Ann Clin Biochem. 1998 Jul;35 ( Pt 4):534-8. doi: 10.1177/000456329803500408.
We have extended automated sequential trace enrichment of dialysates and high performance liquid chromatography to include the simultaneous assay of lamotrigine with other anticonvulsant drugs: phenobarbitone, carbamazepine and phenytoin. The procedure is reliable and precise (between-batch coefficients of variation < 2.8%) with no interference from other commonly prescribed drugs. Patients on lamotrigine presented with serum concentrations up to 67 mumol/L with no adverse effects, suggesting that the therapeutic range may need re-appraisal.
我们扩展了透析液的自动连续痕量富集和高效液相色谱法，以包括同时测定拉莫三嗪与其他抗惊厥药物：苯巴比妥、卡马西平和苯妥英。该方法可靠且精确（批间变异系数<2.8%），不受其他常用处方药的干扰。服用拉莫三嗪的患者血清浓度高达67μmol/L，且无不良反应，这表明治疗范围可能需要重新评估。
