Synthesis and inhibitory activity of novel tri- and tetracyclic quinolines against topoisomerases.
作者信息
Sui Z, Altom J, Nguyen V N, Fernandez J, Bernstein J I, Hiliard J J, Barrett J F, Podlogar B L, Ohemeng K A
机构信息
R. W. Johnson Pharmaceutical Research Institute, Drug Discovery, Raritan, NJ 08869, USA.
出版信息
Bioorg Med Chem. 1998 Jun;6(6):735-42. doi: 10.1016/s0968-0896(98)00030-3.
PMID:9681139
Abstract
A series of isoindolo[2,1-a]- and pyrrolo[1,2-a]quinolines were designed and synthesized for DNA-gyrase and topoisomerase-II inhibition studies. Some of the compounds showed significant activity against the enzymes.
摘要
Zotero 插件