Prinarakis E E, Tzouvelekis L S, Legakis N J
Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
Chemotherapy. 1998 Jul-Aug;44(4):260-4. doi: 10.1159/000007122.
The in vitro activity of loracarbef was evaluated against Escherichia coli strains producing TEM extended-spectrum beta-lactamases (ESBLs). The MICs of loracarbef were lower than those of cefaclor and cephalothin. The antibiotic was active (MICs < or = 2 mg/l) against strains producing TEM-6, TEM-8, TEM-10, TEM-16, TEM-26 and TEM-28 beta-lactamases. The MICs for TEM-3-, TEM-5- and TEM-24-producing strains were higher (> or = 16 mg/l). Hydrolysis studies indicated that the latter beta-lactamases inactivated loracarbef more efficiently than the remaining TEM-type ESBLs examined.
评价了氯碳头孢对产TEM型超广谱β-内酰胺酶（ESBLs）的大肠埃希菌菌株的体外活性。氯碳头孢的最低抑菌浓度（MICs）低于头孢克洛和头孢噻吩。该抗生素对产TEM-6、TEM-8、TEM-10、TEM-16、TEM-26和TEM-28β-内酰胺酶的菌株具有活性（MICs≤2mg/L）。产TEM-3、TEM-5和TEM-24菌株的MICs较高（≥16mg/L）。水解研究表明，与所检测的其余TEM型ESBLs相比，后几种β-内酰胺酶使氯碳头孢失活的效率更高。
