Nishimura R, Hosoba T, Ide M, Seiwa H
Department of Health Sciences, School of Medicine, Hiroshima University, Higashi-Hiroshima, Japan.
Psychiatry Clin Neurosci. 1998 Jun;52(3):303-9. doi: 10.1046/j.1440-1819.1998.00393.x.
We conducted a survey with the Lynfield obsessive-compulsive symptom questionnaire (revised version) on 48 obsessive-compulsive neurotic patients as the survey subjects. In the factor analysis five factors of obsessions, were identified: (i) the desire for perfection; (ii) compulsive checking; (iii) washing; (iv) feelings of uncleanliness; and (v) anthropophobia. High correlations were noted between these factors. We also investigated the premorbid personalities of obsessive-compulsive neurotic patients with a multidimensional personality scale and obtained an extroversion dimension and neuroticism dimension. The influence of these premorbid personality dimensions on obsessive-compulsive symptoms became clear; (i) neuroticism is related to the levels of obsession after onset, but not related to compulsive behaviors; and (ii) No differences in premorbid personality dimensions were noted between compulsive checking and compulsive washing behaviors. We also studied whether it was possible to predict the efficacy of pharmacotherapy upon obsessive-compulsive symptoms. It was elucidated that the obsessions of those whose premorbid personalities are emotionally stable and extroversive are susceptible to antidepressants. Based on these results, we discussed the usefulness of premorbid personalities in predicting diversity of obsessive-compulsive symptoms, as well as in prediction the efficacy of medication.
我们使用林菲尔德强迫症症状问卷（修订版）对48名强迫性神经症患者进行了调查，以他们作为调查对象。在因子分析中，确定了强迫观念的五个因子：（i）对完美的渴望；（ii）强迫检查；（iii）清洗；（iv）不洁感；以及（v）社交恐惧症。这些因子之间存在高度相关性。我们还使用多维人格量表调查了强迫性神经症患者的病前人格，得出了外向性维度和神经质维度。这些病前人格维度对强迫症状的影响变得清晰起来：（i）神经质与发病后的强迫观念水平相关，但与强迫行为无关；（ii）强迫检查行为和强迫清洗行为在病前人格维度上没有差异。我们还研究了是否有可能预测药物治疗对强迫症状的疗效。结果表明，病前人格情绪稳定且外向的患者的强迫观念对抗抑郁药敏感。基于这些结果，我们讨论了病前人格在预测强迫症状多样性以及预测药物疗效方面的有用性。
