Onizuka M, Ishikawa S, Ishibashi O, Suga M, Mitsui K, Mitsui T
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Surg Today. 1998;28(6):618-25. doi: 10.1007/s005950050194.
We studied the effects of thrombin generation due to surgical stress on prostanoid formation and peripheral circulation in anesthetized dogs. Three experimental groups were used, consisting of a control group (group 1), a thoracotomized group (group 2), and a thoracotomized group treated with thrombin inhibitor (MD805: a synthetic arginine derivative) (group 3). The plasma concentrations of thrombin-antithrombin III complex (TAT) and prostanoids were measured along with the hemodynamic parameters. The plasma concentrations of TAT and thromboxane B2 significantly increased 1h after a thoracotomy in group 2. However, neither concentration increased after a thoracotomy in group 3. The flow ratio of the brachial and femoral arteries to cardiac output significantly decreased 1h after a thoracotomy in group 2. This study indicates that thromboxane A2 was thus synthesized by the stimulation of endogenous thrombin, while it also reduced the peripheral blood flow after surgery.
我们研究了手术应激导致的凝血酶生成对麻醉犬类前列腺素形成和外周循环的影响。使用了三个实验组，包括一个对照组（第1组）、一个开胸组（第2组）和一个用凝血酶抑制剂（MD805：一种合成精氨酸衍生物）治疗的开胸组（第3组）。测量了凝血酶 - 抗凝血酶III复合物（TAT）和前列腺素的血浆浓度以及血流动力学参数。第2组开胸术后1小时，TAT和血栓素B2的血浆浓度显著升高。然而，第3组开胸术后这两种浓度均未升高。第2组开胸术后1小时，肱动脉和股动脉与心输出量的血流比显著降低。本研究表明，内源性凝血酶的刺激可合成血栓素A2，同时它也会降低术后外周血流量。
