Harada K, Ohmori M, Kito Y, Fujimura A
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Eur J Clin Pharmacol. 1998 May;54(3):227-30. doi: 10.1007/s002280050450.
To compare the venoconstricting effect of dopamine with that of noradrenaline and to investigate the influence of age on the responsiveness to dopamine in human subjects.
In eight young and eight elderly male subjects, increasing doses of dopamine or noradrenaline were infused into a dorsal hand vein and its diameter was measured using a linear variable differential transformer.
There was no significant difference between the maximum venoconstriction (Emax) for dopamine and that for noradrenaline. The infusion rate to induce 50% of Emax (ED50) for dopamine in the young and elderly subjects was 363 ng x min(-1) and 352 ng min(-1), and the ED50 for noradrenaline was 40.7 ng min(-1) and 43.8 ng x min(-1), respectively. Neither in the Emax nor in the ED50 for these drugs were there significant differences between the young and elderly subjects.
The venoconstricting effect of dopamine is 5-20 times less than that of noradrenaline, and aging does not influence the responsiveness to dopamine and noradrenaline in human subjects.
比较多巴胺与去甲肾上腺素的静脉收缩作用，并研究年龄对人体多巴胺反应性的影响。
对8名年轻男性和8名老年男性受试者，将递增剂量的多巴胺或去甲肾上腺素注入手背静脉，并用线性可变差动变压器测量静脉直径。
多巴胺的最大静脉收缩作用（Emax）与去甲肾上腺素的最大静脉收缩作用之间无显著差异。年轻和老年受试者中诱导50% Emax（ED50）的多巴胺输注速率分别为363 ng·min⁻¹和352 ng·min⁻¹，去甲肾上腺素的ED50分别为40.7 ng·min⁻¹和43.8 ng·min⁻¹。年轻和老年受试者在这些药物的Emax和ED50方面均无显著差异。
多巴胺的静脉收缩作用比去甲肾上腺素小5至20倍，且衰老不影响人体对多巴胺和去甲肾上腺素的反应性。
