Kim J Y, Cho K J, Lee S S, Khang S K, Shim Y S
Department of Anatomic Pathology, Korea Cancer Center Hospital, Seoul.
J Korean Med Sci. 1998 Jun;13(3):269-74. doi: 10.3346/jkms.1998.13.3.269.
The clinicopathologic and immunohistochemical characteristics of nine cases of basaloid squamous carcinoma (BSC) of the upper aerodigestive tract are reported, along with the results of an in situ hybridization for human papilloma virus (HPV) DNA. The cases were selected through a review of 237 head and neck carcinomas, and were located in the supraglottic larynx (5), hypopharynx (2), and the base of tongue (2). The patients were 7 males and 2 females with the mean age of 62. BSCs were histologically characterized by lobules and nests of basaloid cells with scanty cytoplasm, comedonecrosis and adenoid features, and by concomitant presence of squamous cell carcinoma. Immunohistochemically, all BSCs showed positivity for high molecular weight cytokeratin (HMW CK) with heterogeneous or diffuse staining pattern, but lacked reactivity for neuroendocrine markers and bcl-2 oncoprotein. No HPV DNA was detected in BSCs. This study reaffirms that BSC is a rare carcinoma with a peculiar topographic distribution and distinct pathologic features.
报告了9例上呼吸道消化道基底样鳞状细胞癌（BSC）的临床病理和免疫组化特征，以及人乳头瘤病毒（HPV）DNA原位杂交结果。通过回顾237例头颈部癌选出这些病例，病变位于声门上喉（5例）、下咽（2例）和舌根（2例）。患者为7名男性和2名女性，平均年龄62岁。BSC的组织学特征为基底样细胞小叶和巢状结构，胞质稀少，粉刺样坏死和腺样特征，同时伴有鳞状细胞癌。免疫组化方面，所有BSC对高分子量细胞角蛋白（HMW CK）呈阳性，染色模式不均一或弥漫，但对神经内分泌标志物和bcl-2癌蛋白无反应。在BSC中未检测到HPV DNA。本研究再次证实，BSC是一种罕见的癌，具有特殊的部位分布和独特的病理特征。
